dna methylation data obtained with the goldengate beadarray (GoldenGate Software Inc)
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Dna Methylation Data Obtained With The Goldengate Beadarray, supplied by GoldenGate Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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1) Product Images from "DNA Methylation in Multiple Myeloma Is Weakly Associated with Gene Transcription"
Article Title: DNA Methylation in Multiple Myeloma Is Weakly Associated with Gene Transcription
Journal: PLoS ONE
doi: 10.1371/journal.pone.0052626
Figure Legend Snippet: (A) Pearson correlation was used to measure linear relationships between DNA methylation and gene expression levels for 1505 CpG probes represented on the GoldenGate Methylation BeadArray. The panels represent examples of a gene with high (left) and low (right) Pearson correlation coefficients when analyzing DNA methylation levels (x axis) against gene expression levels (y axis). (B) A discretization approach was used to classify samples into methylated (M) or unmethylated (U) groups based on the mean ( μ ) methylation value and standard deviation ( σ ) of a given probe. Statistically significant gene expression differences between M and U groups indicated a methylation-expression correlation for the gene in question.
Techniques Used: DNA Methylation Assay, Expressing, Methylation, Standard Deviation
Figure Legend Snippet: Box plots represent gene expression levels generated by either microarray or qRT-PCR. Data are shown for samples classified as U or M based on the methylation status of p16 (A), DLC1 (B), IGF1R (C), or IL17RB (D). For microarray data, probe intensities are plotted on the y-axis. Relative fold-change differences are plotted for data generated by qRT-PCR. The number of samples in each group is displayed above each plot. The GoldenGate BeadArray probe names are indicated above each pair of box plots.
Techniques Used: Expressing, Generated, Microarray, Quantitative RT-PCR, Methylation